Paclitaxel and cisplatin chemotherapy for metastatic urothelial carcinoma after failure of two courses of platinum-based regimens

作者：Joung Jae Young; Kwon Whi An; Cho In Chang; Kim Eun Kyung; Park Sohee; Yoon Hyekyoung; Seo Ho Kyung; Chung Jinsoo; Park Weon Seo; Lee Kang Hyun^*

来源：International Journal of Urology, 2011, 18(5): 350-357.

DOI：10.1111/j.1442-2042.2011.02735.x

• chemotherapy
• cisplatin
• paclitaxel
• urothelial carcinoma

Objectives:
We investigated the outcomes of paclitaxel and cisplatin chemotherapy as an optional regimen for patients with metastatic urothelial carcinoma after failure of two consecutive platinum-based regimens.
Methods:
We retrospectively analyzed the data of 21 patients who had evidence of disease progression after two consecutive platinum-based regimens, gemcitabine and cisplatin (GC course), and methotrexate, vinblastine, doxorubicin and cisplatin (M-VAC course) as first-line and second-line treatments. As third-line chemotherapy, patients received paclitaxel (175 mg/m2) and cisplatin (70 mg/m2) every 3 weeks until disease progression.
Results:
Complete remission occurred in one patient (4.8%), partial remission occurred in three patients (14.3%) and stable disease occurred in five patients (23.8%). The overall response rate was 19.0% and the overall disease control rate, including stable disease, was 42.9%. The median progression-free survival (PFS) was 3 months (95% CI 3.0-5.0). The median overall survival was 9 months (95% CI 7.0-15.0). Grade 3 to 4 neutropenia appeared in 85.7% of patients. No life-threatening complications were observed.
Conclusions:
Paclitaxel and cisplatin chemotherapy could be an optional regimen for patients with metastatic urothelial carcinoma after the failure of two consecutive standard platinum-based regimens.

• 出版日期2011-5