AMMONIUM IODIDE-PROMOTED CYCLIZATION OF ARYL-SUBSTITUTED CARBOXYLIC ACIDS

作者:Zhang, Bijun; Han, Liuquan; Li, Tingting; Yan, Jie; Yang, Zhenping*
来源:Synthetic Communications, 2014, 44(11): 1608-1613.
DOI:10.1080/00397911.2013.864773

摘要

An efficient procedure was developed for direct preparation of aryl-substituted lactones from corresponding aryl carboxylic acids, which was promoted by ammonium iodide. In this protocol, aryl carboxylic acids were treated with ammonium iodide, potassium bromide, and oxidant Oxone in a mixture of acetonitrile and 2,2,2-trifluoroethanol (6:4) at room temperature for 12 h, resulting in corresponding aryl lactones in moderate to good yields.