科研之友
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摘要
Herein, we describe a chemical system combining asymmetric amplification of Soai's autocatalyst alongside a catalytic addition of Zn(iPr)(2) to azaaryl aldehydes. Thus, Soai autocatalyst is amplified in situ from 11 to > 98% ee and concomitantly catalyzes the alkylation of pyridine aldehydes to provide alkanols with up to 99% ee. Also, exceptional amplifications of ee in one cycle are observed for both compounds produced throughout the reaction, probably as a result of interactions in a reaction network coupling enantioselective autocatalysis and asymmetric induction.
- 出版日期2015-7
