Asymmetric Synthesis of Furo[3,4-b]indoles by Catalytic [3+2] Cycloaddition of Indoles with Epoxides

作者：Chen Weiliang; Xia Yong; Lin Lili; Yuan Xiao; Guo Songsong; Liu Xiaohua; Feng Xiaoming^*

来源：Chemistry - A European Journal, 2015, 21(43): 15104-15107.

DOI：10.1002/chem.201502448

• asymmetric synthesis
• epoxides
• indoles
• N
• N-dioxide-metal complex

A highly efficient N,N-dioxide-Ni-II catalyst system for the catalytic [3+2] cycloaddition of indoles with epoxides through CC cleavage of oxiranes was accomplished under mild conditions. It provided a promising approach for chiral furo[3,4-b]indoles in up to 98% yield with up to 91% enantiomeric excess (ee) and >95:5 diastereomeric ratio (d.r.).

• 出版日期2015-10-19
• 单位四川大学