A Meta-analysis on the Effect of Ulinastatin on Serum Levels of C-Reactive Protein, Interleukin 6, and Tumor Necrosis Factor Alpha in Asian Patients with Acute Pancreatitis

作者：Zhang, Chunze^*; Wang, Yijia; Fu, Wenzheng; Zhang, Weihua; Wang, Tao; Qin, Hai

来源：Genetic Testing and Molecular Biomarkers, 2016, 20(3): 118-124.

DOI：10.1089/gtmb.2015.0192

• ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY
• BIAS
• HETEROGENEITY
• HEPATECTOMY
• GUIDELINES

Objectives: We aimed to investigate the influence of ulinastatin (UTI) on the serum levels of C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-) in Asian patients with acute pancreatitis (AP) by performance of a meta-analysis. Methods: Two investigators independently searched 11 databases, including PUBMED, EBSCO, Ovid, SpringerLink, Wiley, Web of Science, Cochrane Library, Wanfang database, China National Knowledge Infrastructure (CNKI), Chinese Journal Full-text Database, and China Biomedicine Database. The full-text articles were screened and the data were extracted using a standardized data extraction form. All statistical analyses were conducted with Stata software, version 12.0 (Stata Corporation, College Station, TX). Results: A total of 94 studies were initially retrieved, and 10 studies containing 424 Asian patients with AP were ultimately enrolled in this meta-analysis. The results revealed that the serum levels of CRP, IL-6, and TNF- in Asian AP patients significantly decreased after UTI therapy (CRP: standardized mean difference [SMD]=3.26, 95% confidence interval [CI]=1.69-4.83, p<0.001; IL-6: SMD=5.92, 95% CI=2.09-9.75, p=0.002; TNF-: SMD=4.07, 95% CI=0.79-7.35, p=0.015). Conclusion: The results of this meta-analysis suggest that UTI can effectively depress the serum levels of CRP, IL-6, and TNF- in Asian patients with AP, and thereby inhibit inflammation.

• 出版日期2016-3-1
• 单位天津市人民医院