Adverse reactions to immunotherapy are associated with different patterns of sensitization to grass allergens

作者：Sastre J^*; Rodriguez F; Campo P; Laffond E; Marin A; Alonso M D

来源：Allergy, 2015, 70(5): 598-600.

DOI：10.1111/all.12575

• grass allergens
• immunotherapy
• molecular diagnosis
• safety

The aim of the study was to investigate whether adverse drug reactions (ADRs) during immunotherapy with a grass extract (AVANZ((R)) Phleum, ALK-Abello) are related to the different patterns of sensitization of patients to grass allergens. A total of 192 patients with rhinitis and/or asthma sensitized to grass pollen received a 4-week updosing with five injections. ADRs were evaluated following EAACI guidelines. A total of 432 ADRs in 133 (69%) patients were recorded, 64% local and 31% systemic. There was a significant association between the number of grass allergens that sensitized the patients and the total number of ADRs (P=0.004) occurred locally (P=0.003) and systemically (P=0.01). Sensitization to Phl p1+Phl p5 or Phl p1+Phl p5+Phl p12 was significantly associated with a higher frequency of local or systemic reactions (P=0.001, both). Different patterns of sensitization to grass allergens may potentially be considered a risk marker to the development of ADRs to immunotherapy.

• 出版日期2015-5