A Facile Synthesis of Functionalized 1,2,6,7-Tetrahydroimidazo[1,5-c]pyrimidine-3,5-diones

作者：Lebed' Pavlo S^*; Kos Pavlo O; Tolmachev Andrey; Vovk Mykhaylo V; Boyko Alexander N; Chekotylo Alexey

来源：Synthetic Communications, 2013, 43(17): 2343-2348.

DOI：10.1080/00397911.2012.707738

• Bis(trichloromethyl)carbonate
• ethyl 6-aminomethyl-2-oxo-5-pyrimidinecarboxylates
• ethyl 6-azidomethyl-2-oxo-5-pyrimidinecarboxylates
• ethyl 3
• 5-dioxoimidazo[1
• 5-c]pyrimidine-8-carboxylates

A Pd-mediated hydrogenation of ethyl 6-azidomethyl-1,2,3,4-tetrahydro-4-R-2-oxo-5-pyrimidinecarboxylates leads to the corresponding ethyl 6-aminomethyl1,2,3,4-tetrahydro-4-R-2-oxo-5-pyrimidinecarboxylates. The latter react with bis(trichloromethyl)carbonate, yielding the title ethyl 1,2,3,5,6,7-hexahydro-7-R-3,5-dioxoimidazo[1,5-c]pyrimidine-8-carboxylates. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) to view the free supplemental file.

• 出版日期2013-9-2