Adjustment of responsive temperature and loading behavior of temperature-sensitive core-shell micelles prepared via in-situ polymerization

作者：Ren Xian Wen; Jiang Ming^*

来源：Chemical Journal of Chinese Universities, 2006, 27(11): 2204-2208.

• core-shell structure
• polymeric micelle
• poly(N-isopropyl acrylamide)
• macromolecular self-assembly

In-situ polymerization, which had been developed in our group, was employed to prepare thermo-sensitive poly (D, L-lactic acid)/poly (N-isopropyl acrylamide-co-acrylamide) (PLA/PNIPAM-co-AM) core-shell micelles. The resultant micelles N-100, N-90 and N-80 were obtained in which the mass fractions of hydrophilic AM units in the feeds were 0, 10% and 20%, respectively. SEM, TEM and AFM were used to observe the morphologies of the micelles and the results confirmed the core-shell structure. The nanoparticles show a significant size change with the variation of temperature. The diameter of N-100 decreases from 207.3 nm to 140.1 nm when temperature increases from 27 degrees C to 41 degrees C. The responsive temperatures of N-100, N-90 and N-80 were found to be 33, 41 and 56 degrees C, respectively, which means that the responsive temperature of the micelles can be adjusted by changing the shell compositions. In addition, the dye-loading behavior of the nanoparticles was also studied.

• 出版日期2006-11-10
• 单位复旦大学