ANTIOXIDANT ACTIVITY OF ASCORBIC ACID ANALOGS CONTAINING A NITROGEN ATOM IN THE RING

作者:Nomura Shogo; Inami Keiko; Mochizuki Masataka*
来源:Heterocycles, 2016, 92(4): 680-687.
DOI:10.3987/COM-16-13410

摘要

Ascorbic acid (AscH(2)) is a powerful antioxidant and protects the human body from oxidative stresses by scavenging reactive oxygen species. AscH(2) analogs containing a carbonyl conjugated ene-diol structure and endocyclic nitrogen atom were evaluated for their oxidation potentials by cyclic and differential pulse voltammetry. The oxidation potentials of AscH(2) analogs in which the endocyclic oxygen atom of AscH(2) was replaced by a single nitrogen atom were lower than those of AscH(2) under both non-aqueous and aqueous conditions. The results demonstrate that these analogs can have powerful antioxidant activities under physiological conditions.

  • 出版日期2016-4-1

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