A HOMOLOG OF THE PROTEASOME-RELATED RING10 GENE IS ESSENTIAL FOR YEAST-CELL GROWTH

作者：FRIEDMAN H; GOEBEL M; SNYDER M

来源：Gene, 1992, 122(1): 203-206.

DOI：10.1016/0378-1119(92)90051-P

• SACCHAROMYCES-CEREVISIAE
• PRG1
• ANTIGEN DEGRADATION
• PROTEOLYSIS

Proteasomes are intracellular protein complexes displaying multiproteolytic activities. These complexes have been implicated in the antigen degradation process that generates peptides associated with the major histocompatibility complex (MHC) class-I molecule. RING10 and RING12 are genes encoded by the class-II region of the human MHC that have sequence homology to proteasome-encoding genes. We have identified a yeast gene, called PRG1, that encodes a protein predicted to contain 55.6% sequence identity to 80% of the RING10 gene product. Genomic disruption of PRG1 revealed that it is essential for yeast cell growth. These data strongly indicate that the antigen-processing system present in vertebrates evolved from a basic cellular process present in all organisms.

• 出版日期1992-12-1