Mechanisms of isolevuglandin-protein adduct formation in inflammation and hypertension

作者：Xiao, Liang; Patrick, David M.; Aden, Luul A.; Kirabo, Annet^*

来源：Prostaglandins & Other Lipid Mediators, 2018, 139: 48-53.

DOI：10.1016/j.prostaglandins.2018.09.008

• Hypertension
• Inflammation
• Isolevuglandins

Inflammation has been implicated in the pathogenesis of hypertension and recent evidence suggests that isolevuglandin (IsoLG)-protein adducts play a role. Several hypertensive stimuli contribute to formation of IsoLG-protein adducts including excess dietary salt and catecholamines. The precise intracellular mechanisms by which these hypertensive stimuli lead to IsoLG-protein adduct formation are still not well understood; however, there is now evidence implicating NADPH-oxidase derived reactive oxygen species (ROS) in this process. ROS oxidize arachidonic acid leading to formation of IsoLGs, which non-covalently adduct to lysine residues and alter protein structure and function. Recent studies suggest that these altered proteins act as neo-antigens leading to an autoimmune state that results in hypertension. The goal of this mini-review is to highlight some of the hypertensive stimuli and the mechanisms contributing to IsoLG-protein adduct formation leading to inflammation and hypertension.

• 出版日期2018-11