科研之友
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摘要
Objectives: The association between interleukin-10 (IL-10) promoter (-1082 A/G, -819 T/C, -592 A/C) polymorphism and haplotyes with systemic lupus erythematosus (SLE) has been investigated in recent years. However, the susceptibility to SLE in different ethnic subjects was various. This study aimed to analyze IL-10 promoter haplotypes in Han Chinese patient with SLE. Methods: 237 Han Chinese patients with SLE and 259 healthy controls (HC) were investigated. Polymerase chain reaction and restriction fragment length polymorphism analysis were used to analyze IL-10 promoter polymorphism (-1082 A/G, -819 T/C, -592 A/C). Results: The -1082 G allele frequency was significantly higher in SLE patients than that in HC (P<0.05, OR=0.358). A significantly higher distribution of -1082 A/G AG genotype was found in SLE patients compared with HC (P<0.05, OR=0.335). The haplotypes ATA, GTA, GCC exhibited higher prevalence in Han Chinese patients with SLE than that in HC. GCC carriers were significantly associated with SLE in Han Chinese population (P<0.01, OR=2.882). However, the haplotype ATC was a significant protective factor for SLE in Han Chinese population (P<0.05, OR=0.675). Our research indicated the contribution of IL-10 promoter GCC haplotype, -1082 A/G AG genotype and G allele to susceptibility to SLE in Han Chinese population, it was different with previous researchs performed in other races and countries. Conclusion: IL-10 promoter GCC haplotype was significantly associated with SLE in Han Chinese population, while the haplotype ATC was significantly protective from SLE in Han Chinese population.
