Airway and tissue mechanics in ventilated patients with pneumonia

作者：Lorx Andras; Suki Bela; Hercsuth Magdolna; Szabo Barna; Penzes Istavn; Boda Krisztina; Hantos Zoltan^*

来源：Respiratory Physiology & Neurobiology, 2010, 171(2): 101-109.

DOI：10.1016/j.resp.2010.03.004

• Respiratory mechanics
• Airway resistance
• Elastance
• Heterogeneity

We applied the low-frequency forced oscillation technique (LFOT) to measure respiratory impedance (Zrs) at various positive end-expiratory pressures (PEEPs) in 14 sedated and intubated patients with pneumonia classified into a mild (Group 1) and a severe group (Group 2) based on lung injury scores The Zrs spectra were fit with the constant-phase (CP) model including Newtonian resistance (RN) and tissue damping (G) and elastance (H). a distributed airway resistance (DR) and a distributed tissue elastance (DH) model. Using the CP model, all parameters revealed a negative PEEP dependence (p < 0 001) in Group 2 and H was higher in Group 2 (p = 0014). The variability of H from the DH model was nearly significantly larger in Group 1 (p = 0061). Following bronchodilator inhalation, G significantly decreased (p = 0009). Thus, the CP model provides a robust partitioning of Zrs i

• 出版日期2010-4-30