Altered Distribution of Juxtaparanodal K(v)1.2 Subunits Mediates Peripheral Nerve Hyperexcitability in Type 2 Diabetes Mellitus

作者：Zenker Jennifer; Poirot Olivier; Charles Anne Sophie de Preux; Arnaud Estelle; Medard Jean Jacques; Lacroix Catherine; Kuntzer Thierry; Chrast Roman^*

来源：Journal of Neuroscience, 2012, 32(22): 7493-7498.

DOI：10.1523/JNEUROSCI.0719-12.2012

Peripheral nerve hyperexcitability (PNH) is one of the distal peripheral neuropathy phenotypes often present in patients affected by type 2 diabetes mellitus (T2DM). Through in vivo and ex vivo electrophysiological recordings in db/db mice, a model of T2DM, we observed that, in addition to reduced nerve conduction velocity, db/db mice also develop PNH. By using pharmacological inhibitors, we demonstrated that the PNH is mediated by the decreased activity of K(v)1-channels. In agreement with these data, we observed that the diabetic condition led to a reduced presence of the K(v)1.2-subunits in juxtaparanodal regions of peripheral nerves in db/db mice and in nerve biopsies from T2DM patients. Together, these observations indicate that the T2DM condition leads to potassium channel-mediated PNH, thus identifying them as a potential drug target to treat some of the DPN related symptoms.

• 出版日期2012-5-30