科研之友
微信
新浪微博
Facebook
分享链接
摘要
Increase of intracellular positive ions (mainly Na+) indicates greater possibility of cell malignancy. The present study investigated the correlation between the Na+ micro-current value (MCV) and tissue characteristics (normal, benign or malignant). 346 tissue samples have been detected within 30 min after surgical isolation by Na+ detector. MCV in 102 malignant tumor was significantly higher than that in benign/borderline tumor or normal tissue (33.3 +/- 8.9 mu A vs. 24.4 +/- 8.6 mu A and 14.0 +/- 4.0 mu A, p < 0.001, respectively). MCV in malignant tumor parenchyma was significantly higher than that in the paired paracanceroustissue, normal tissue and surgical margin tissue (33.3 +/- 8.9 mu A vs. 18.9 +/- 4.1, 14.2 +/- 4.0 or 15.2 +/- 3.3, p < 0.001, respectively). However, the coincidence rate between Na+ detector and pathological examination was different in tissues from different organs or systems, which was high in pancreas, bile duct system, gastrointestinal system, esophagus, breasts, lungs, nose & throat and thyroids, but poor in urinary tissue. The overall coincidence rate was 83.1% (108/130) between Na+ detector and pathological examination. The sensitivity and specificity of correct diagnosis by Na+ detector was 83.3% (70/84) and 82.6% (38/46), respectively. This new modality may have diagnostic potential in complementing frozen examination in differentiating malignant tumor from benign or normal tissue, justifying tumor metastatic scope and confirming surgical margin.
