科研之友
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摘要
BACKGROUND AND PURPOSE: Time-resolved MRA imaging is a promising technique for blood flow evaluation in case of cerebrovascular malformations. Unfortunately, 4D MRA imaging is a trade-off between spatial and temporal resolution. The aim of this study was to investigate the influence of temporal resolution on the error associated with UP estimation from indicator dilution curves derived from different vascular structures. %26lt;br%26gt;MATERIALS AND METHODS: Monte Carlo simulation was performed to compute indicator dilution curves with known criterion standard UP at temporal resolutions between 0.1 and 5 seconds. TTPs were estimated directly and by using 4 hemodynamic models for each curve and were compared with criterion standard TIP. Furthermore, clinical evaluation was performed by using 226 indicator dilution curves from different vessel structures obtained from clinical datasets. The temporal resolution was artificially decreased, and TTPs were estimated and compared with those obtained at the original temporal resolutions. The results of the clinical evaluations were further stratified for different vessel structures. %26lt;br%26gt;RESULTS: The results of both evaluations show that the TIP estimation error increases exponentially when one lowers the temporal resolution. UP estimation by using hemodynamic model curves leads to lower estimation errors compared with direct estimation. A temporal resolution of 1.5 seconds for arteries and 2.5 seconds for venous and arteriovenous malformation vessel structures appears to be reasonable to achieve UP estimations adequate for clinical application. %26lt;br%26gt;CONCLUSIONS: Different vessel structures require different temporal resolutions to enable comparable TIP estimation errors, which should be considered for achieving a case-optimal temporal and spatial resolution.
- 出版日期2012-12
- 单位河北医科大学
