A novel gold-based molecular beacon for probing CNG DNA repeat sequences

作者：Joo Han Na; Seo Young Jun^*

来源：Tetrahedron Letters, 2015, 56(3): 542-545.

DOI：10.1016/j.tetlet.2014.12.004

• DNA
• CNG repeat
• Oligonucleotide
• Fluorophore
• Gold nanoparticles

We designed and developed a novel gold-based molecular beacon that targets CAG and CTG DNA repeat sequences. In single-stranded closed-loop state, the gold-based CNG repeat probe is quenched by an attached gold nanoparticle. Upon encounter with its target CAG or CTG repeat sequence, the probe forms a linear duplex structure and exhibits increased emission signal. This is the first gold quencher-based molecular beacon targeting the CNG repeat.

• 出版日期2015-1-14