Animal models reveal role for tau phosphorylation in human disease

作者：Goetz Juergen; Gladbach Amadeus; Pennanen Luis; van Eersel Janet; Schild Andreas; David Della; Ittner Lars M

来源：Biochimica et Biophysica Acta-Molecular Basis of Disease, 2010, 1802(10): 860-871.

DOI：10.1016/j.bbadis.2009.09.008

• Alzheimer's disease
• Amyloid
• Drosophila
• Frontotemporal dementia
• Kinase
• Mice
• Nematode
• Phosphatase
• Phosphorylation
• Tau
• Transgenic

Many proteins that are implicated in human disease are posttranslationally modified. This includes the microtubule-associated protein tau that is deposited in a hyperphosphorylated form in brains of Alzheimer's disease patients. The focus of this review article is on the physiological and pathological phosphorylation of tau; the relevance of aberrant phosphorylation for disease; the role of kinases and phosphatases in this process; its modeling in transgenic mice, flies, and worms; and implications of phosphorylation for therapeutic intervention.

• 出版日期2010-10