Anethum graveolens seeds aqueous extract stimulates whole brain 5-hydroxytryptamine metabolism and reduces feeding behavior and body weight in obese rats

作者：Bano Farhat^*; Ahmed Afrinah; Ahmed Maryam; Parveen Tahira

来源：Pakistan Journal of Pharmaceutical Sciences, 2015, 28(1): 221-225.

• Anethum graveolens seeds aqueous extract (AGAE)
• 5-hydroxytryptamine (5-HT)
• 5-hydroxy Indol Acetic Acid (5-HIAA)
• High Performance Liquid Chromatography(HPLC)
• Tryptophen (TRP)

The percentage of overweight and obese person has increased markedly since several decays. Obesity is associated with increased risked factor for many diseases such as, diabetes, heart complications, arthritis and certain types of cancer. Feeding behavior is in controlled by a major interaction between central nervous system and many organs of the body. The role of serotonin (5-HT) in feeding behavior is well recognized. The aim of present study was to evaluate the effect of Anethum graveolens seeds aqueous extract (AGAE), on food intake, body weight and serotonin metabolism in over weight rats. Five weeks oral administration of AGAE shows significant decrease in body weight, food intake and significant increase in whole brain 5-HT, 5-HIAA and tryptophan level in brain and plasma of experimental animals. Increased level of 5-HT induced satiety and suppressed food intake and result is the reduction in body weight.

• 出版日期2015-1