Vitamin K3 and vitamin C alone or in combination induced apoptosis in leukemia cells by a similar oxidative stress signalling mechanism

作者：Bonilla Porras Angelica R; Jimenez Del Rio Marlene; Velez Pardo Carlos^*

来源：Cancer Cell International, 2011, 11: 19.

DOI：10.1186/1475-2867-11-19

Background: Secondary therapy-related acute lymphoblastic leukemia might emerge following chemotherapy and/or radiotherapy for primary malignancies. Therefore, other alternatives should be pursued to treat leukemia.
Results: It is shown that vitamin K3-or vitamin C-induced apoptosis in leukemia cells by oxidative stress mechanism involving superoxide anion radical and hydrogen peroxide generation, activation of NF-kappa B, p53, c-Jun, protease caspase-3 activation and mitochondria depolarization leading to nuclei fragmentation. Cell death was more prominent when Jurkat and K562 cells are exposed to VC and VK3 in a ratio 1000: 1 (10 mM: 10 mu M) or 100: 1 (300 mu M: 3 mu M), respectively.
Conclusion: We provide for the first time in vitro evidence supporting a causative role for oxidative stress in VK3and VC-induced apoptosis in Jurkat and K562 cells in a domino-like mechanism. Altogether these data suggest that VK3 and VC should be useful in the treatment of leukemia.

• 出版日期2011-6-10