Mixed lineage leukemia: histone H3 lysine 4 methyltransferases from yeast to human

作者：Malik Shivani; Bhaumik Sukesh R^*

来源：FEBS Journal, 2010, 277(8): 1805-1821.

DOI：10.1111/j.1742-4658.2010.07607.x

• ASH1
• ASH2
• COMPASS
• histone H3 lysine 4
• histone methyltransferase
• MLL
• Set1
• TAC1
• TRX
• WDR5

The fourth lysine of histone H3 is post-translationally modified by a methyl group via the action of histone methyltransferase, and such a covalent modification is associated with transcriptionally active and/or repressed chromatin states. Thus, histone H3 lysine 4 methylation has a crucial role in maintaining normal cellular functions. In fact, misregulation of this covalent modification has been implicated in various types of cancer and other diseases. Therefore, a large number of studies over recent years have been directed towards histone H3 lysine 4 methylation and the enzymes involved in this covalent modification in eukaryotes ranging from yeast to human. These studies revealed a set of histone H3 lysine 4 methyltransferases with important cellular functions in different eukaryotes, as discussed here.

• 出版日期2010-4