Marinocyanins, cytotoxic bromo-phenazinone meroterpenoids from a marine bacterium from the streptomycete Glade MAR4

作者：Asolkar Ratnakar N; Singh Ahilya; Jensen Paul R; Aalber**erg William; Carte Brad K; Feussner Klaus D; Subramani Ramesh; DiPasquale Antonio; Rheingold Arnold L; Fenical William^*

来源：Tetrahedron, 2017, 73(16): 2234-2241.

DOI：10.1016/j.tet.2017.03.003

• Bromophenazinones
• MAR4 actinomycete
• Meroterpenoids

Six cytotoxic and antimicrobial metabolites of a new bromo-phenazinone class, the marinocyanins A-F (1-6), were isolated together with the known bacterial metabolites 2-bromo-1-hydroxyphenazine (7), lavanducyanin (8, WS-9659A) and its chlorinated analog WS-9659B (9). These metabolites were purified by bioassay-guided fractionation of the extracts of our MAR4 marine actinomycete strains CNS-284 and CNY-960. The structures of the new compounds were determined by detailed spectroscopic methods and marinocyanin A (1) was confirmed by crystallographic methods. The marinocyanins represent the first bromo-phenazinones with an N-isoprenoid substituent in the skeleton. Marinocyanins A-F show strong to weak cytotoxicity against HCT-116 human colon carcinoma and possess modest antimicrobial activities against Staphylococcus aureus and amphotericin-resistant Candida albicans.

• 出版日期2017-4-20