Anatomic Pathology of Hepatocellular Carcinoma: Impact on Prognosis and Response to Therapy

作者：Roskams Tania^*

来源：Clinics in Liver Disease, 2011, 15(2): 245-+.

DOI：10.1016/j.cld.2011.03.004

• Dysplastic nodules
• Early HCC
• Hepatic progenitor cells
• Liver biopsy
• K19
• Glypican 3
• HSP70
• Glutamine synthetase

A better understanding of signaling pathways in HOC pathogenesis has led to targeted therapies against HOC. Identification of liver cancer stem cell markers and their related pathways is one of the most important goals of liver cancer research. New therapies should ideally target cancer stem cells and not normal stem/progenitor cells, because the latter are very important in regeneration and repair. Individualized HOC therapy will require better definition of patient subgroups that benefit most or should be protected from therapy failure and unwanted side effects. Tumor tissue acquisition should be mandatory, reversing the practice that was established years ago when targeted HOC therapy was but a pope dream.

• 出版日期2011-5