Antimicrobial Stewardship in the Management of Sepsis

作者：Pulia Michael S^*; Redwood Robert; Sharp Brian

来源：Emergency Medicine Clinics of North America, 2017, 35(1): 199-+.

DOI：10.1016/j.emc.2016.09.007

• Antimicrobial stewardship
• Antibiotics
• Sepsis
• Clinical decision support
• Biomarkers
• Rapid pathogen identification assays
• Quality measures
• Emergency medicine

Sepsis represents a unique clinical dilemma with regard to antimicrobial stewardship. The standard approach to suspected sepsis in the emergency department centers on fluid resuscitation and timely broad-spectrum antimicrobials. The lack of gold standard diagnostics and evolving definitions for sepsis introduce a significant degree of diagnostic uncertainty that may raise the potential for inappropriate antimicrobial prescribing. Intervention bundles that combine traditional quality improvement strategies with emerging electronic health record-based clinical decision support tools and rapid molecular diagnostics represent the most promising approach to enhancing antimicrobial stewardship in the management of suspected sepsis in the emergency department.

• 出版日期2017-2