A High Dose of Intravenous Immunoglobulin Increases CD94 Expression on Natural Killer Cells in Women with Recurrent Spontaneous Abortion

作者：Shimada Shigeki; Takeda Masamitsu; Nishihira Jun; Kaneuchi Masanori; Sakuragi Noriaki; Minakami Hisanori; Yamada Hideto^*

来源：American Journal of Reproductive Immunology, 2009, 62(5): 301-307.

DOI：10.1111/j.1600-0897.2009.00739.x

• CD94
• immunoglobulin
• natural killer cell

Problem
A high dose of intravenous immunoglobulin (HIVIg) therapy is effective in various diseases such as autoimmune diseases, and also is expected to have efficacy in recurrent spontaneous abortion (RSA). The aim of this study was to understand immunological mechanisms of this therapy.
Method of study
By flowcytometric analyses, we examined phenotypic changes of a variety of immunological cells including natural killer (NK) cells, cytotoxic T cells, regulatory T cells and macrophages in peripheral blood of RSA women with HIVIg therapy (n = 8).
Results
Expression percentages of inhibitory CD94 on NK cells significantly (P = 0.01) increased after the therapy (58.8 +/- 21.4% versus 71.0 +/- 17.6%).
Conclusion
Mechanisms of possible efficacy of HIVIg therapy for RSA may include enhancement of CD94 expression and subsequent suppression of NK cell cytotoxicity.

• 出版日期2009-11