An environmentally benign benzylic oxidation catalyzed by hypervalent iodine intermediate in water

作者：Xu, Yuan; Hu, Jian Tao; Yan, Jie^*

来源：Chinese Chemical Letters, 2012, 23(8): 891-894.

DOI：10.1016/j.cclet.2012.06.002

• Benzylic oxidation
• Hypervalent iodine intermediate
• Catalytic reaction
• Synthesis

An effective and environmentally benign benzylic oxidation for transition of alkylarenes into the corresponding carbonyl compounds was reported. Alkylarenes were mixed and stirred with potassium bromide, m-chloroperbenzoic acid and a catalytic amount of iodobenzene in water at 60 degrees C for several hours, a series of the corresponding carbonyl compounds was obtained in moderate to good yields. In the reaction, iodobenzene was first oxidized by m-chloroperbenzoic acid into the hypervalent iodine intermediate which then reacted with potassium bromide to form the key radical initiator for the benzylic oxidation.

• 出版日期2012-8
• 单位浙江工业大学