A In Vitro and In Vivo Study of the Ability of NOD1 Ligands to Activate the Transcriptional Factor NF-kB

作者：Tukhvatulin A I^*; Logunov D Y; Gitlin I I; Shmarov M M; Kudan P V; Adzhieva A A; Moroz A F; Kostyukova N N; Burdelya L G; Naroditsky B S; Gint**urg A L; Gudkov A V

来源：Acta Naturae, 2011, 3(1): 77-84.

DOI：10.32607/20758251-2011-3-1-77-84

• pattern-recognition receptors
• Toll-like receptors
• NOD1-receptor
• transcriptional factor NF-kB
• peptidoglycan of gram-negative bacteria

Pattern-recognition receptors (PRR) play a crucial role in the induction of the defense reactions of the immune system against pathogenic bacterial and viral infections. The activation of PRR by specific, highly conserved pathogen-associated molecular patterns (PAMPs) induces numerous immune reactions related both to innate and adaptive immunity. In addition to the well-studied Toll-like receptors, pathogens can be recognized by the receptors belonging to the other PRR families; including NOD-like receptors (NLR). Stimulation of members of NOD-like receptors (NOD 1, 2) and Toll-like receptors results in the activation of the transcriptional factor NF-kB regulating gene expression in numerous molecules implicated in the development of proinflammatory reactions. As opposed to Toll-like receptors, the NF-kB-activating ability of NLRs has not been fully studied. In this work, we examine the ability of one member of the NLR family - NOD1 - to activate the main proinflammatory transcriptional factor NF-kB. We also compare the NF-kB-activating ability of NOD1 ligands of a different structure with TLR4,5 ligands in vitro and in vivo.

• 出版日期2011-3