Under Correction of Sagittal Deformities Based on Age-adjusted Alignment Thresholds Leads to Worse Health-related Quality of Life Whereas Over Correction Provides No Additional Benefit

作者：Scheer Justin K; Lafage Renaud; Schwab Frank J; Liabaud Barthelemy; Smith Justin S; Mundis Gregory M; Hostin Richard; Shaffrey Christopher I; Burton Douglas C; Hart Robert A; Kim Han J; Bess Shay; Gupta Munish; Lafage Virginie^*; Ames Christopher P

来源：Spine, 2018, 43(6): 388-393.

DOI：10.1097/BRS.0000000000002435

• adult spinal deformity
• age
• age-adjusted alignment
• threshold
• health-related quality of life
• sagittal alignment
• sagittal balance
• sagittal malalignment
• spinopelvic alignment
• over correction

Study Design. Retrospective review of prospectively-collected database.
Objective. This study aims to compare 2-year clinical outcomes of patients who underwent surgical reconstructions based on their achievement to age-adjusted alignment ideals.
Summary of Background Data. Recent research in sagittal plane has proposed age-adjusted alignment thresholds. However, the impact of these thresholds on postoperative healthrelated quality of life (HRQOL) is yet to be investigated.
Methods. Patients were included if they were more than 18-years old and underwent surgical correction of adult spinal deformity with a complete 2-year follow-up. Patients were stratified into three groups based on achievement of age-adjusted thresholds in pelvic tilt (PT), pelvic incidence minus lumbar lordosis (PI-LL), and sagittal vertical axis (SVA). First group included patients who reached the exact age-adjusted threshold +/- 10 years (MATCHED), other two groups included patients who were over corrected (OVER), and under corrected (UNDER). Clinical outcomes including actual value and offset from age-adjusted Oswestry Disability Index, Short-Form-36 (SF-36) -physical component summary, and Scoliosis Research Society-22r (SRS-22r) were compared between groups at 2 years follow-up.
Results. A total of 343 patients (mean, 57 yrs and 83% females) were included. Sagittal profile of the population was: PT = 23.6 degrees, SVA = 65.8 mm, and PI-LL = 15.68. At 2-year follow-up, there was significant improvement in all sagittal modifiers with 25.7%, 24.3%, and 33.1% of the patients matching their age alignment targets in terms of PT, PI-LL, and SVA, respectively. For PT and PI-LL, the three groups (MATCHED, OVER, and UNDER) had comparable values and offsets from age-adjusted PROM. However, for SVA groups, patients in UNDER had significantly worse HRQOL than the two other groups. Patients in PT, PI-LL, and SVA UNDER groups were significantly younger than the other groups, P < 0.05.
Conclusion. At 2 years after adult spinal deformity surgical treatment, only 24.3% to 33.1% of the patients reached ageadjusted alignment thresholds. Those under corrected in SVA demonstrated worse clinical outcomes. No significant improvements were found between matched and overcorrected patients, with overcorrection being an established risk for proximal junctional kyphosis. These results further emphasize the need for patient specific operative planning.

• 出版日期2018-3-15