N-phenylmaleimide derivatives as mimetic agents of the pro-inflammatory process: myeloperoxidase activation

作者：Noldin Vania F; Vigil Silvana V G; De Liz Rafael; Cechinel Filho Valdir; Froede Tania S; Creczynski Pasa Tania B^*

来源：Pharmacological Reports, 2011, 63(3): 772-780.

• N-phenylmaleimides
• myeloperoxidase
• inflammation
• neutrophils
• hypochlorous acid

Myeloperoxidase (MPO) is an important enzyme that catalyzes the reaction between hydrogen peroxide and chloride to generate hypochlorous acid, which oxidizes a range of biomolecules and has been associated with inflammatory diseases. The synthetic compounds N-phenylmaleimide (NFM) and 4-methyl-N-phenylmaleimide (Me-NFM) increased the MPO activity in vitro (of isolated enzyme and in isolated cells after animal treatment) and in vivo assays. MPO-induction may represent a good model system to investigate the molecular and cellular mechanisms of oxidative cell injury induced by activated neutrophils, and the interactions between damaging species involved in the respiratory burst.

• 出版日期2011-6