Bone Repair Stimulation in Rat Mandible by New Chitosan Silver(I) Complexes

作者：Ibrahim Fatima M; El Hawary Yousry M; Butler Ian S; Mostafa Sahar I^*

来源：International Journal of Polymeric Materials and Polymeric Biomaterials, 2014, 63(16): 846-858.

DOI：10.1080/00914037.2014.886222

• Ahmp
• bone generation
• chitosan
• rat mandible
• silver

Two new chitosan silver(I) complexes, [Ag(2CS)(H2O)(NO3)] and [Ag(2CS)(ahmp)(H2O)] (CS chitosan, Hahmp = 4-amino-6-hydroxy- 2-mercaptopyrimidine) were synthesized and characterized on the basis of elemental analysis, spectral (FT-IR and solid-state C-13-NMR), morphological (SEM, matrix analysis, XRD, and XRPE), and thermal measurements. Chitosan behaves as a neutral ligand, coordinates Ag(I) through half of amino nitrogen centers, with the pendant glucose amine hydroxy functionality playing no role in coordination, while 4-amino-6-hydroxy-2-mercaptopyrimidine functions as mononegative bidentate, chelating through the deprotonated cyclic nitrogen and thione sulfur atoms. [Ag(2CS)(ahmp)(H2O)] displays a significant potential bone regenerator in rat mandible. Forty male rats were divided into two groups: bone defect (control) and bone defect with [Ag(2CS)(ahmp)(H2O)] (treated). The bone defects were stained with hematoxylin and eosin, and Masson%26apos;s trichrome for histological analysis. The treated group shows faster and well organized bone formation in the defect in comparison to the control group which shows little new bone trabeculae and wide marrow cavities.

• 出版日期2014
• 单位McGill