Dual imaging-guided photothermal/photodynamic therapy using micelles

作者：Guo, Miao; Mao, Huajian; Li, Yanli; Zhu, Aijun; He, Hui; Yang, Hong; Wang, Yangyun; Tian, Xin; Ge, Cuicui; Peng, Qiaoli; Wang, Xianyong; Yang, Xiangliang; Chen, Xiaoyuan; Liu, Gang; Chen, Huabing^*

来源：Biomaterials, 2014, 35(16): 4656-4666.

DOI：10.1016/j.biomaterials.2014.02.018

• Micelles
• Photosensitizer
• Near infrared fluorescent imaging
• Photoacoustic imaging
• Photothermal therapy
• Photodynamic therapy

We report a type of photosensitizer (PS)-loaded micelles integrating cyanine dye as potential theranostic micelles for precise anatomical tumor localization via dual photoacoustic (PA)/near-infrared fluorescent (NIRF) imaging modalities, and simultaneously superior cancer therapy via sequential synergistic photothermal therapy (PTT)/photodynamic therapy (PDT). The micelles exhibit enhanced photostability, cell internalization and tumor accumulation. The dual NIRF/PA imaging modalities of the micelles cause the high imaging contrast and spatial resolution of tumors, which provide precise anatomical localization of the tumor and its inner vasculature for guiding PTT/PDT treatments. Moreover, the micelles can generate severe photothermal damage on cancer cells and destabilization of the lysosomes upon PTT photo-irradiation, which subsequently facilitate synergistic photodynamic injury via PS under PDT treatment. The sequential treatments of PTT/PDT trigger the enhanced cytoplasmic delivery of PS, which contributes to the synergistic anticancer efficacy of PS. Our strategy provides a dual-modal cancer imaging with high imaging contrast and spatial resolution, and subsequent therapeutic synergy of PTT/PDT for potential multimodal theranostic application.

• 出版日期2014-5
• 单位华中科技大学; 苏州大学; 厦门大学