A Short Biomimetic Synthesis of the Meroterpenoids Guajadial and Psidial A

作者：Lawrence Andrew L; Adlington Robert M; Baldwin Jack E; Lee Victor^*; Kershaw Jessica A; Thompson Amber L

来源：Organic Letters, 2010, 12(8): 1676-1679.

DOI：10.1021/ol100138k

The biosynthesis of the meroterpenoid guajadial was previously hypothesized to occur via a hetero-Diels Alder reaction between caryophyllene and an o-quinone methide. This hypothesis has been verified via the biomimetic synthesis of guajadial and psidial A in an aqueous three-component coupling reaction, between caryophyllene, benzaldehyde, and diformylphloroglucinol.

• 出版日期2010-4-16