Antibacterial efficacy of aminoglycosidic antibiotics protected gold nanoparticles - A brief study

作者：Grace A Nirmala; Pandian K^*

来源：Colloids and Surfaces A: Physicochemical and Engineering Aspects , 2007, 297(1-3): 63-70.

DOI：10.1016/j.colsurfa.2006.10.024

• gold nanoparticles
• aminoglycosidic antibiotics
• microbial activity

Gold nanoparticles have been used as a probe for the detection of various aminoglycosidic antibiotics like streptomycin, gentamycin and neomycin. The nature of interaction between these drugs and gold nanoparticles has been probed by various analytical techniques like UV-vis, FIF-IR, TEM, etc. Such studies can be used for the determination of drugs in drug formulations. Further in vitro antibacterial activities of drugs capped An nanoparticles (Au@drugs) were investigated against various strains of Gram positive and Gram negative organisms viz. Staphylococcus aureus, Micrococcus luteus, E. Coli and Pseudomonas aeruginosa. Our results suggest that gold nanoparticles could act as an effective drug carrier in drug delivery system.

• 出版日期2007-4-5