A utilitarian comparison of two alcohol use biomarkers with self-reported drinking history collected in antenatal clinics

作者：May Philip A; Hasken Julie M; De Vries Marlene M; Marais Anna Susan; Stegall Julie M; Marsden Daniel; Parry Charles D H; Seedat Soraya; Tabachnick Barbara

来源：Reproductive Toxicology, 2018, 77: 25-32.

DOI：10.1016/j.reprotox.2018.02.002

• Alcohol
• Biomarkers of alcohol use
• Self-report of alcohol use
• Phosphatidylethanol (PEth)
• Ethyl glucuronide (EtG)
• AUDIT
• Quantity and frequency of drinking

Background: Alcohol use is reported accurately among pregnant women in some populations.
Methods: Self-reported alcohol use via the AUDIT and 90-day recall for 193 women from antenatal clinics was compared to biomarker results: phosphatidylethanol (PEth) from bloodspots and ethyl glucuronide (EtG) in fingernails.
Results: AUDIT was positive for 67.9% of respondents, and 653% directly reported drinking. Individual biomarkers detected less drinking (PEth = 57.0%, EtG = 38.9%) than self-report. But 64.8% had drinking positive values (>8 ng) on one or both biomarkers, which was not significantly different from self-report. Biomarkers indicated that 3.1% -6.8% of drinkers denied drinking. Combined biomarker sensitivity was 95%-80% and specificity 49% -76% for drinking in the previous 7-90 days. Combined biomarker results have their best yield (89.6%) and accuracy (78.8%) when measuring 90 day drinking.
Conclusions: Women reported their alcohol use accurately, and the combined use of PEth and EtG is supported.

• 出版日期2018-4