A placebo-controlled study to assess Standardized Field Sobriety Tests performance during alcohol and cannabis intoxication in heavy cannabis users and accuracy of point of collection testing devices for detecting THC in oral fluid

作者：Bosker W M^*; Theunissen E L; Conen S; Kuypers K P C; Jeffery W K; Walls H C; Kauert G F; Toennes S W; Moeller M R; Ramaekers J G

来源：Psychopharmacology, 2012, 223(4): 439-446.

DOI：10.1007/s00213-012-2732-y

• Cannabis
• Delta(9)-Tetrahydrocannabinol
• THC
• SFST
• DUID
• Oral fluid
• Alcohol
• Drug
• Drug abuse
• Cannabinoids

Standardized Field Sobriety Tests (SFST) and oral fluid devices are used to screen for driving impairment and roadside drug detection, respectively. SFST have been validated for alcohol, but their sensitivity to impairment induced by other drugs is relatively unknown. The sensitivity and specificity for Delta(9)-tetrahydrocannabinol (THC) of most oral fluid devices have been low. %26lt;br%26gt;This study assessed the effects of smoking cannabis with and without alcohol on SFST performance. Presence of THC in oral fluid was examined with two devices (Drager Drug TestA (R) 5000 and Securetec DrugwipeA (R) 5). %26lt;br%26gt;Twenty heavy cannabis users (15 males and 5 females; mean age, 24.3 years) participated in a double-blind, placebo-controlled study assessing percentage of impaired individuals on the SFST and the sensitivity of two oral fluid devices. Participants received alcohol doses or alcohol placebo in combination with 400 mu g/kg body weight THC. We aimed to reach peak blood alcohol concentration values of 0.5 and 0.7 mg/mL. %26lt;br%26gt;Cannabis was significantly related to performance on the one-leg stand (p = 0.037). Alcohol in combination with cannabis was significantly related to impairment on horizontal gaze nystagmus (p = 0.029). The Drager Drug TestA (R) 5000 demonstrated a high sensitivity for THC, whereas the sensitivity of the Securetec DrugwipeA (R) 5 was low. %26lt;br%26gt;SFST were mildly sensitive to impairment from cannabis in heavy users. Lack of sensitivity might be attributed to tolerance and time of testing. SFST were sensitive to both doses of alcohol. The Drager Drug TestA (R) 5000 appears to be a promising tool for detecting THC in oral fluid as far as correct THC detection is concerned.

• 出版日期2012-10