A one-pot four-component synthesis of N-arylidene-2-aryl-imidazo[1,2-a]azin-3-amines

作者：Rahmati Abbas^*; Moazzam Ali; Khalesi Zahra

来源：Tetrahedron Letters, 2014, 55(29): 3840-3843.

DOI：10.1016/j.tetlet.2014.03.098

• Multi-component reactions
• Imidazo[1,2-a]pyrazines
• Imidazo[1,2-a]pyridine

N-Arylidene-2-aryl-imidazo[1,2-a]azin-3-amines were synthesized via a one-pot, four-component condensation reaction using a 2-aminoazine, toluene-4-sulfonylmethyl isocyanide (TsCH2NC), and two equivalents of readily available aromatic aldehydes. The reaction was performed in diethyl ether as the solvent, with p-toluenesulfonic acid (p-TSA) as the catalyst at reflux temperature.

• 出版日期2014-7-16