MSCT multi-criteria: A novel approach in assessment of mediastinal lymph node metastases in non-small cell lung cancer

作者：Volterrani Luca; Mazzei Maria Antonietta^*; Banchi Benedetta; Voltolini Luca; La Sala Filomena; Carbone Salvatore Francesco; Ricci Veronica; Gotti Giuseppe; Zompatori Maurizio

来源：European Journal of Radiology, 2011, 79(3): 459-466.

DOI：10.1016/j.ejrad.2010.03.027

• Multi-slice computed tomography
• Non-small cell lung cancer
• Mediastinal lymph nodes

Purpose: To evaluate the accuracy of multi-slice computed tomography (MSCT) in diagnosing mediastinal lymph node metastases in patients with non-small cell lung cancer (NSCLC) using a multi-criteria approach.
Methods: We retrospectively reviewed contrast-enhanced MSCT of the chest in 86 consecutive patients with histopathologically proven NSCLC. All patients underwent surgical lymph node resection within 30 days from the CT examination. In all cases pathological and CT results were reviewed and correlated.
Results: The sensitivity, specificity, positive and negative predictive values, and accuracy of MSCT using a multi-criteria approach in the detection of the N2 stage were 100%, 98.5%, 100%, 94.4% and 98.8% respectively, whereas using the size criterion alone 64%, 61%, 87%, 40%, and 62% respectively.
Conclusions: To improve MSCT accuracy for diagnosing N staging other criteria can be associated with lymph node size. The use of different dimensional cut-offs for each mediastinal lymph node station, the matching of positive nodal stations with tumour location, the structural characteristics and the type of enhancement allow for a high accuracy of MSCT in the staging of mediastinal nodes in NSCLC.

• 出版日期2011-9