New 2-oxosparteine derivatives: Synthesis and spectroscopic characterization

作者：Kurek Joanna^*; Jasiewicz Beata; Wyrzykiewicz Elzbieta; Boczon Wladyslaw

来源：Journal of Molecular Structure, 2011, 1003(1-3): 10-20.

DOI：10.1016/j.molstruc.2011.06.045

• Bis-quinolizidine alkaloids
• 2-Oxosparteine derivatives
• Grignard's reaction
• FT-IR
• NMR
• MS

New 2-oxosparteine derivatives with alkyl (n-propyl-, n-pentyl-, n-hexyl- and n-heptyl-) substituent at C-17 position have been synthesized and studied by (1)H, (13)C NMR, MS, FT-IR and theoretical methods. It has been shown that alkyl substituent introduced at C-17 position is equatorially oriented and does not change the boat conformation of ring C. All newly obtained derivatives, when treated with HClO(4) give only monoperchlorate salts.

• 出版日期2011-9-28