In Vitro Synergism between Azithromycin or Terbinafine and Topical Antimicrobial Agents against Pythium insidiosum

作者：Itaqui Sabrina R; Verdi Camila M; Tondolo Juliana S M; da Luz Thaisa S; Alves Sydney H; Santurio Janio M; Loreto Erico S^*

来源：Antimicrobial Agents and Chemotherapy, 2016, 60(8): 5023-5025.

DOI：10.1128/AAC.00154-16

We describe here in vitro activity for the combination of azithromycin or terbinafine and benzalkonium, cetrimide, cetylpyridinium, mupirocin, triclosan, or potassium permanganate. With the exception of potassium permanganate, the remaining antimicrobial drugs were active and had an MIC90 between 2 and 32 mu g/ml. The greatest synergism was observed for the combination of terbinafine and cetrimide (71.4%). In vivo experimental evaluations will clarify the potential of these drugs for the topical treatment of lesions caused by Pythium insidiosum.

• 出版日期2016-8