MurA as a Primary Target of Tulipalin B and 6-Tuliposide B

作者：Shigetomi, Kengo; Olesen, Sanne Harder; Yang, Yan; Mitsuhashi, Shinya; Schoenbrunn, Ernst; Ubukata, Makoto^*

来源：Bioscience Biotechnology and Biochemistry, 2013, 77(12): 2517-2519.

DOI：10.1271/bbb.130663

• tuliposide
• tulipalin
• MurA

(-)-Tulipalin B and (+)-6-tuliposide B were confirmed to inhibit MurA in vitro. However, contrary to fosfomycin, these compounds showed potent inhibitory activities against MurA overexpressing Escherichia coli, especially in the presence of UDP-GlcNAc. These observations suggest that these compounds induced bacterial cell death not through a MurA malfunction, but in such a MurA-mediated indirect manner as the inhibition of other Mur enzymes.

• 出版日期2013-12