Detecting spatial memory deficits beyond blindness in tg2576 Alzheimer mice

作者：Yassine Nour; Lazaris Anelise; Dorner Ciossek Cornelia; Despres Olivier; Meyer Laurence; Maitre Michel; Mensah Nyagan Ayikoe Guy; Cassel Jean Christophe; Mathis Chantal^*

来源：Neurobiology of Aging, 2013, 34(3): 716-730.

DOI：10.1016/j.neurobiolaging.2012.06.016

• Alzheimer disease
• APP transgenic mice
• Object location
• Recognition memory
• Barnes maze
• Spatial memory
• Vision
• Blind mice
• Retinal degeneration
• Genetic background
• B6SJL mice

The retinal degeneration Pde6b(rd1) (rd) mutation can be a major pitfall in behavioral studies using tg2576 mice bred on a B6:SJL genetic background, 1 of the most widely used models of Alzheimer%26apos;s disease. After a pilot study in wild type mice, performance of 8- and 16-month-old tg2576 mice were assessed in several behavioral tasks with the challenge of selecting 1 or more task(s) showing robust memory deficits on this genetic background. Water maze acquisition was impossible in rd homozygotes, whereas Y-maze alternation, object recognition, and olfactory discrimination were unaffected by both the transgene and the rd mutation. Spatial memory retention of 8- and 16-month-old tg2576 mice, however, was dramatically affected independently of the rd mutation when mice had to recognize a spatial configuration of objects or to perform the Barnes maze. Thus, the latter tasks appear extremely useful to evaluate spatial memory deficits and to test cognitive therapies in tg2576 mice and other mouse models bred on a background susceptible to visual impairment.

• 出版日期2013-3