Memory T cells in cutaneous leishmaniasis

作者：Glennie Nelson D; Scott Phillip^*

来源：Cellular Immunology, 2016, 309: 50-54.

DOI：10.1016/j.cellimm.2016.07.010

• Leishmania
• Memory T cells
• Vaccine

Leishmania causes a spectrum of diseases that range from self-healing to fatal infections. Control of leishmania is dependent upon generating CD4+ Th1 cells that produce IFN gamma, leading to macrophage activation and killing of the intracellular parasites. Following resolution of the disease, short-lived effector T cells, as well as long-lived central memory T cells and skin resident memory T cells, are retained and able to mediate immunity to a secondary infection. However, there is no vaccine for leishmaniasis, and the drugs used to treat the disease can be toxic and ineffective. While a live infection generates immunity, a successful vaccine will depend upon generating memory T cells that can be maintained without the continued presence of parasites. Since both central memory and skin resident memory T cells are long-lived, they may be the appropriate targets for a leishmaniasis vaccine.

• 出版日期2016-11