Preparation and antitubercular activity of lipophilic diamines and amino alcohols

作者：Junior Celso O R; le Hyaric Mireille; da Costa Cristiane F; Correa Tais A; Taveira Aline F; Araujo Debora P; Reis Elaine F C; Lourenco Maria Cristina S; Vicente Felipe R C; de Almeida Mauro V^*

来源：Memorias do Instituto Oswaldo Cruz, 2009, 104(5): 703-705.

DOI：10.1590/s0074-02762009000500006

• tuberculosis
• amino alcohols
• diamines
• lipophilicity

A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 mu g/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 mu g/mL.

• 出版日期2009-8