Modifying Influence of Dietary Sugar in the Relationship Between Cortisol and Visceral Adipose Tissue in Minority Youth

作者：Gyllenhammer Lauren E^*; Weigen**erg Marc J; Spruijt Metz Donna; Allayee Hooman; Goran Michael I; Davis Jaimie N

来源：Obesity, 2014, 22(2): 474-481.

DOI：10.1002/oby.20594

Objective: Cortisol has been associated with preferential visceral adipose tissue (VAT) deposition; however, findings in humans are mixed, which may be clarified when diet is considered.
Design and Methods: Participants included 165 African-American and Latino, overweight adolescents (BMI% 97.2 +/- 3.2%, ages 13-18, 67% Latino, 66% female). Body composition was determined by dual energy X-ray absorptiometry, abdominal fat depots [VAT, subcutaneous (SAT)] by multiple-slice MRI, time-controlled serum sample to measure cortisol, and 2-day multi-pass 24-hour dietary recall. Linear regression analysis examined the cross-sectional relationship between cortisol, and the interaction of diet and cortisol on adiposity measures. Sex, race, age, and total body fat were a priori covariates.
Results: There was a significant interaction between cortisol and sugar (total and added) in the prediction of VAT (P-interaction <= 0.05). Amongst participants with high total or added-sugar intake, cortisol was significantly associated with VAT (beta = 0.031 P < 0.001; beta = 0.026 P < 0.001), with no relationship in low consumers of total or added-sugar.
Conclusion: Dietary sugar may play an important role in modifying the relationship between cortisol and VAT, such that cortisol is significantly associated with elevated VAT under conditions of high sugar intake.

• 出版日期2014-2