Association of-619C/T polymorphism in CDSN gene and psoriasis risk: a meta-analysis

作者：Wu Y; Wang B; Liu J L; Gao X H; Chen H D; Li Y H^*

来源：Genetics and Molecular Research, 2011, 10(4): 3632-3640.

DOI：10.4238/2011.October.21.6

• Corneodesmosin
• Psoriasis
• Gene polymorphism
• Risk
• Meta-analysis

Previous studies investigating the association between corneodesmosin (CDSN) polymorphisms and psoriasis risk have provided inconsistent results. The aim of our study was to clarify the effects of CDSN -619C/T polymorphism on psoriasis risk by conducting a meta-analysis. We conducted searches of the published literature in Pubmed and Embase databases up to October 2010. Six studies with a total of 842 psoriasis cases and 981 healthy controls were retrieved. Statistical analysis was performed with the programs Review Manager (version 5.0.24) and Stata (version 9.2). Meta-analysis results showed that there was no significant difference in CDSN -619C/T genotype distribution between psoriasis and control in the comparisons of C allele vs T allele, CC vs CT + TT, CC + CT vs TT, CC vs TT, and CC vs CT (respectively: OR = 1.28, 95% CI = 0.82-2.00, P = 0.28; OR = 1.33, 95% CI = 0.80-2.21, P = 0.28; OR = 1.23, 95% CI = 0.80-1.91, P = 0.35; OR = 1.41, 95% CI = 0.64-3.12, P = 0.40; OR = 1.30, 95% CI = 0.81-2.06, P = 0.27). In the subgroup analysis by ethnicity, results also showed no significant association between CDSN -619C/T polymorphism and susceptibility to psoriasis in both Caucasian and Asian populations. In conclusion, this meta-analysis suggests that CDSN -619C/T polymorphism may not be associated with susceptibility to psoriasis.

• 出版日期2011
• 单位中国医科大学