Macrocytic anemia is associated with the severity of liver impairment in patients with hepatitis B virus-related decompensated cirrhosis: a retrospective cross-sectional study

作者：Yang, Jian; Yan, Bin; Yang, Lihong; Li, Huimin; Fan, Yajuan; Zhu, Feng; Zheng, Jie; Ma, Xiancang^*

来源：BMC Gastroenterology, 2018, 18(1): 161.

DOI：10.1186/s12876-018-0893-9

• Macrocytic anemia
• HBV-related decompensated cirrhosis
• MELD score
• Severity of liver impairment

BackgroundMacrocytic anemia is common in liver disease. However, its role in hepatitis B virus (HBV)-related decompensated cirrhosis remains unknown. The aim of the present study was to determine the association between macrocytic anemia and the severity of liver impairment in patients with HBV-related decompensated cirrhosis according to the Model for End Stage Liver Disease (MELD) score.MethodsA total of 463 participants who fulfilled our criteria were enrolled in this cross-sectional study. Patients were classified into three groups according to anemia types, diagnosed based on their mean corpuscular volume level. Multivariate linear regression analyses were used to determine the association between macrocytic anemia and the MELD score for patients with HBV-related decompensated cirrhosis.ResultsPatients with macrocytic anemia had evidently higher MELD scores (10.86.6) than those with normocytic anemia (8.0 +/- 5.5) or microcytic anemia (6.3 +/- 5.1). The association remained robust after adjusting for age, gender, smoking, drinking, and total cholesterol (=1.94, CI: 0.81-3.07, P<0.001).ConclusionsMacrocytic anemia was found to be associated with the severity of liver impairment and might be a predictor for short-term mortality in patients with HBV-related decompensated cirrhosis.

• 出版日期2018-11-1
• 单位西安交通大学