A systematic review of resting-state functional-MRI studies in major depression

作者：Wang L; Hermens D F; Hickie I B; Lagopoulos J^*

来源：Journal of Affective Disorders, 2012, 142(1-3): 6-12.

DOI：10.1016/j.jad.2012.04.013

• Resting state
• fMRI
• Depression
• Bipolar
• Affective disorders
• Connectivity

Background: To evaluate the literature pertaining to the use of resting-state functional magnetic resonance imaging (fMRI) in Major Depression (MD).
Methods: A search for papers published in English was conducted using MedLine, Embase, PsycINFO, OvidSP, and ScienceDirect with the following words: resting state, depression, MRI, affective, and default-mode.
Results: The findings from 16 resting-state fMRI studies on MD are tabulated. Some common findings are discussed in further detail.
Conclusion: The use of resting-state fMRI in MD research has yielded a number of significant findings that provide the basis for understanding the pathophysiology of depressive symptoms. Of particular note and deserving of further research are the roles of the cortico-limbic mood regulating circuit (MRC) and the interaction between task-positive and task-negative networks in MD. There is increasing interest in the use of resting-state fMRI in the study of psychiatric conditions, and continued improvement in technique and methodology will prove valuable in future research.

• 出版日期2012-12-15