Novel 3D printed alginate-BFP1 hybrid scaffolds for enhanced bone regeneration

作者：Heo Eun Young; Ko Na Re; Bae Min Soo; Lee Sang Jin; Choi Byung Joon; Kim Jung Ho; Kim Hyung Keun; Park Su A; Kwon Ii Keun

来源：Journal of Industrial and Engineering Chemistry, 2017, 45: 61-67.

DOI：10.1016/j.jiec.2016.09.003

• Tissue engineering
• Hydrogel scaffold
• BFP1
• 3D printing
• Bone regeneration

In this research, novel 3D printed alginate-peptide hybrid scaffolds were explored for enhanced bone regeneration. Bone formation peptide-1 (BFP1) was loaded into the scaffolds to promote bone regeneration. The alginate-BFP1 conjugates were synthesized via a facile EDC/NHS coupling reaction and then cross-linked in the presence of calcium ions to form hydrogel networks. The dose-dependent cytotoxicity of CaCl2 was evaluated to optimize the amount of Ca2+ for fabrication of scaffolds. In vitro and in vivo studies indicated that the alginate-based scaffolds provided a stable environment for the growth of human adipose-derived stem cells (hADSCs) and led to a synergistically enhanced bone regeneration.

• 出版日期2017-1-25