Asymmetric organocatalytic reduction of ketimines with catecholborane employing a N-triflyl phosphoramide Bronsted acid as catalyst

作者：Enders Dieter^*; Rembiak Andreas; Seppelt Matthias

来源：Tetrahedron Letters, 2013, 54(6): 470-473.

DOI：10.1016/j.tetlet.2012.11.055

• Organocatalysis
• Bronsted acid
• Ketimine
• Catecholborane
• Reduction

The first asymmetric reduction of ketimines with catecholborane employing an enantiopure N-triflyl phosphoramide as the organocatalyst has been developed. Five mole % of the catalyst provides the corresponding secondary amines in very good to almost quantitative yields and good enantioselectivities up to 86:14 e.r. under mild reaction conditions.

• 出版日期2013-2-6