A novel ferrocenyl-naphthalimide as a multichannel probe for the detection of Cu(II) and Hg(II) in aqueous media and living cells

作者：Dong, Junyang; Hu, Jianfeng; Baigude, Huricha; Zhang, Hao^*

来源：Dalton Transactions, 2018, 47(2): 314-322.

DOI：10.1039/c7dt03982d

• HIGHLY SELECTIVE DETECTION
• RATIOMETRIC FLUORESCENT CHEMOSENSOR
• TURN-ON PROBE
• DIFFERENTIAL DETECTION
• CHANNEL DETECTION
• MOLECULAR SWITCH
• TRANSITION-METAL
• HG2+
• REDOX
• IONS

A novel ferrocenyl-naphthalimide multichannel probe 1 was designed and synthesized using a facile method. The color of the solution containing probe 1 changed from yellow to colorless upon the addition of Cu2+ or Hg2+. Interestingly, probe 1 exhibited highly selective fluorescent turn-on for Cu2+ and turnoff for Hg2+ in aqueous solution. Probe 1 was an electrochemical Cu2+ and Hg2+ ion sensor, in which the Fc/Fc(+) redox couple was significantly shifted (Delta E-1/2 = 178 mV and Delta E-1/2 = 53 mV, respectively) upon complexation. Therefore, probe 1 can act as a naked-eye chemosensor, as well as an electrochemical and a fluorescent probe for Cu2+ and Hg2+. Furthermore, this is the first reported probe that can be used for the bifunctional fluorescent detection of intracellular Cu2+ and Hg2+ by fluorescent imaging studies. These characteristics give this probe considerable potential in the study and analysis of Cu2+ and Hg2+ in complex biosystems.

• 出版日期2018-1-14
• 单位高分子物理与化学国家重点实验室; 中国科学院长春应用化学研究所; 内蒙古大学